Tottenhamhave confirmed that Cristian Romero will missthis afternoon's game against Aston Villaafter suffering an injury during the warm-up.
Romero, 27, hadn't missed a single minute for Spurs in the Premier League this season, but his streak will come to an end, as he won't face Villa.
He went to warm up with the rest of his Tottenham teammates but is said to have felt some discomfort and headed straight down the tunnel.
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Kevin Danso will replace the Argentina international in the starting line-up and partner Micky van de Ven, who will captain the side, in central defence.
As for the rest of the XI, Guglielmo Vicario will start in goal, while Pedro Porro and Djed Spence are the two full-backs with Destiny Udogie out injured.
Rodrigo Bentancur and Joao Palhinha make up the defensive midfield duo, with Xavi Simons ahead of them both in the No.10 position.
Wilson Odobert and Mohammed Kudus are out wide while Mathys Tel is the No.9 with Dominic Solanke still unavailable and Richarlison on the bench.
Romero was later spotted in the tunnel alongside Argentina teammate Emiliano Martinez before the two teams walked out at the Tottenham Hotspur Stadium.

He then took his place on the bench as he prepared to watch his side in action, looking to record a second straight win after a 2-1 win at Leeds United before the international break.
Tottenham's clash against Villa is the first of seven in 22 days during a hectic period for Frank and his side. Speaking about that pre-match, the Spurs head coach said: "We love to play games.
"Every footballer loves to play a game instead of training. Coaches, we like to train a little bit more sometimes, but in general, we love to play the games. We have a fantastic run of games ahead of us, starting with Villa on Sunday – a top team, top manager, Unai, I respect him a lot. I think what he's done in his career is amazing.
"What he created at Villa is fantastic in so many areas. I think they did well in the Champions League last season and almost qualified for the Champions League again, which is very impressive and I think they have a very strong team. So, yeah, looking forward to it."
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